"She told me I would get 12 points today," Krapohl said. "She looked me right in the eye and said I would get four 3s."
Krapohl indeed hit four 3-pointers and scored 12 points - in the first 18 minutes of the game.
"People were finding me, and I was wide open on most of my shots," Krapohl said.
Alana Beard scored 15 points, Brittany Hunter had 14 and Jessica Foley added 11 for the Blue Devils (18-3, 9-1 ACC), who rebounded from an 80-74 loss to Florida State on Wednesday.
Monique Currie tied the Duke school record for assists with 12 after getting 11 by halftime.
Krapohl led Duke in scoring for the first time in the 113 games she has played. She scored 15 first-half points, and Duke led 49-16 at halftime.
"We talked to Vicki about her shooting," Duke coach Gail Goestenkors said. "We told her, 'You need to search for your shot. It's not enough just to shoot when you're open."'
Fallon Stokes scored 15 to lead Georgia Tech (11-11, 2-8), which lost its third straight overall.
Vicki Krapohl is congratulated by teammates near the end of the game after scoring a career-high 18 points to lead No. 2 Duke to an 81-41 win.
Coming off the loss to the Seminoles, which snapped Duke's 51-game conference winning streak, the Blue Devils jumped out to a 23-2 lead on Georgia Tech. They never let the Yellow Jackets closer than 18 points after that.
"They came off the Florida State loss playing with a lot more intensity and, I thought, a lot more passion," Georgia Tech coach MaChelle Joseph said.
Duke still has a streak going of 24 straight ACC wins at home.
"I think this game was good for our confidence," Krapohl said. "I can't remember the last time we were all smiling together on the court. This was a fun game to play in."
Duke played its second straight game without Tillis, who sustained a concussion Monday in a 78-60 win at Clemson and missed the loss to the Seminoles.
Tillis, averaging 11.9 points and 6.8 rebounds a game, is expected to be ready for Duke's game against Wake Forest on Thursday.
The Blue Devils forced 19 turnovers in the first half and pulled away steadily after the break. They led by as many as 48.
Georgia Tech made a season-low 14 field goals on 47 attempts (29.8 percent). The Yellow Jackets shot worse only once this season, hitting 29 percent against Davidson.