Beard made 11 of 13 shots in a 28-point performance in her final regular season home game to lead the third-ranked Blue Devils to a 102-45 victory Friday night over Clemson - the worst defeat in Tigers history.
Beard's performance left her with 2,555 points in 128 games, one shy of the Duke scoring record held by current men's assistant coach Johnny Dawkins.
The Blue Devils (23-3, 14-1 Atlantic Coast Conference) close the league's regular season play against North Carolina State on Monday night.
"I'm aware of that," Beard said of being two points shy of the record. "N.C. State is another game, and we have to compete in that and every game in the ACC. It's not really about the individual thing right now."
Beard also had three steals and a game-high nine rebounds in just 27 minutes of play.
"Alana had a great night," Duke coach Gail Goestenkors said. "But she was cramping up at the end when she came out. I didn't want to risk injury by putting her back in."
Goestenkors' decision to sit Beard with 7:12 left to play was about the only thing that failed to delight the home crowd.
Duke won its sixth straight as five Blue Devils players scored in double digits.
"That was just a fun game to be in," Beard said.
Monique Currie added 13 points, Iciss Tillis 11, and Lindsey Harding and Brittany Hunter 10 apiece for Duke.
Julie Aderhold scored 11 points for Clemson (17-9, 7-8). The worst previous showing by the Tigers was a 112-58 loss at Old Dominion on Nov. 30, 1979.
"That wasn't a whipping. That was a whupping," Tigers coach Jim Davis said. "That team is going to beat us 99 times out of 100. I was just foolish enough to think that this was going to be the one."
Davis' teams had not previously allowed more than 100 points in regulation in his 18 seasons as coach.
Beard and Harding each scored 10 points as Duke rolled to a 48-20 halftime lead. Beard scored nine of Duke's first 11 points after halftime, as the Blue Devils began the second half with a 13-3 run and never again let Clemson closer than 66-29 thereafter.
It was the last regular season game in Cameron Indoor Stadium for Duke seniors Beard, Tillis and Vicki Krapohl, although the Blue Devils will host a set of NCAA first- and second-round games March 21-23.
"We're not all that emotional about this game," Tillis said. "We still have two more home games, and I won't be emotional until we play out last game, period, like in the championship game."