Leading 9-0, the Seminoles' much-maligned quarterback Chris Rix, threw across the middle in heavy pressure and was intercepted by Duke's Cody Lowe at midfield. Lowe returned the ball 26 yards to the Florida State 24 setting up the game's first touchdown, eight plays later when Cedric Dargan punched it in from one yard out to cut the lead to 9-7.
Florida State returned to the field under the command of backup quarterback Wyatt Sexton, who would lead his team to three long scoring drives in the second half, which put the game away.
Sexton completed 11 of 15 passes for 220 yards and a touchdown while taking the Seminoles on drives of 93, 80 and 70 yards to break the game open with 20 unanswered points.
Meanwhile the Duke offense once again showed sparks, but was ultimately ineffective as Mike Schneider was picked off three times, while fumbling once along with Senterrio Landrum as Duke turned it over five times on the day. Schneider finished the day 19-of-31 for just 155 yards with the three picks.
The Blue Devils also struggled to run the ball against the talented Seminoles, logging just 61 yards on 33 carries, led by freshman Ronnie Drummer's 24 yards on one carry. Dargan finished with just 23 yards on 12 carries.
The loss drops Duke to 1-8 on the season and 0-6 in the ACC with Clemson and North Carolina both coming to Durham in the next two weeks to close out the season. Meanwhile Florida State improved to 7-2 and 5-2 in conference play on the season.