Nolan Smith hit consecutive 3-pointers 30 seconds apart to start the decisive run for the Blue Devils (17-1, 4-0 Atlantic Coast Conference). They closed the game on a 27-5 run and shot 76 percent in the second half.
Kyle Singler had 14 of his 17 points in the second half and Smith finished with 13 to help Duke overcome a horrible start. Brandon Costner and Ben McCauley both scored 15 points for the Wolfpack (10-6, 1-3), who led for much of the way but hit just one field goal over the final 7:45 minutes.
That cold spell helped Duke claim its 12th straight victory at Cameron Indoor Stadium over NC State, which hasn't won inside the Blue Devils' famously hostile arena since 1995.
Duke returns to action on Saturday when Maryland comes to town. Tip-off is scheduled for noon.