Receiver Donovan Varner finished the day with 11 receptions for 174 yards and two touchdowns. Varner caught 65 passes for 1,047 yards in 2009 to become just the third player in Duke history with over 1,000 yards receiving in a single season.
Receivers Conner Vernon and Austin Kelly both collected 93 receiving yards, while tailback Desmond Scott totaled 252 all-purpose yards on the afternoon. Senior linebacker Vincent Rey paced the Blue Devil defense with 11 tackles.
Both offenses dominated the first quarter as the two teams combined for 329 total yards and four touchdowns in the opening 7:39. Duke struck first, 1:04 into the first quarter on the third play of the day with a 56-yard touchdown pass from Lewis to Varner.
The Blue Devils took the lead again, needing only 1:04 and three plays to reach the end zone. This time, Lewis found Kelly breaking through the middle for a 62-yard gain.
On Wake Forest's following possession, the Blue Devil defense forced a punt, but a personal foul penalty gave the Deacons the ball back near midfield. Wake's offense capitalized on the Duke miscue, knotting the score at 14-all on a 54-yard touchdown pass from Skinner to receiver Chris Givens.
The Demon Deacons took the lead for good early in the second quarter, covering 55 yards in eight plays. Skinner tossed his third touchdown pass of the game, again finding Brown for an eight-yard strike.
On Duke's following possession, tailback Jay Hollingsworth rushed for two first downs to push the Devil offense across midfield, but Duke stalled in Wake territory. However, Kicker Will Snyderwine connected on a 51-yard field goal attempt, the longest of his career, and the Blue Devils trailed 21-17 heading into halftime.
Yet the third quarter would belong to the Demon Deacons, with Skinner throwing for 154 yards and two touchdowns in the period, including a 13-yard strike to tailback Kevin Harris and a 51-yard pass to receiver Marshall Williams.
Duke was able to add a field goal in the third quarter, but trailed 35-20 heading into the fourth. A missed Wake field goal gave the Devils the ball back, and Lewis punched the ball in from the one-yard line to cut Wake's lead to 35-27 after an 80-yard drive.
But the Blue Devils could not narrow the lead any farther and Wake Forest would add a field goal and run back an interception to take a 45-27 lead late in the fourth quarter. Duke added another touchdown, a 21-yard reception by Varner, with 2:31 left in the game, but Wake Forest was able to run out the clock for win.