The Dukes, coming off shooting 55 percent against Niagara on Friday, still had the hot hand in the first half, making 13-of-27 shots including 5-of-10 3-pointers.
Samantha Thompson's 3-pointer with 1:10 remaining in the half gave the Dukes its largest lead of the half, 11 points, at 33-22 before TU's Kandace Davis' foul shot closed out the first half scoring with DU taking a 33-23 lead into halftime.
The Dukes would build a 12 point lead with 14:52 to go in the second half. However, the Tigers would continue to chip away at the lead over the next nine minutes and a Shanae Baker-Brice jumper at the 5:46 mark would tie the contest at 50-50.
A Haiena Snowden layup gave TU their first lead since the first minute of regulation, 52-50 with 5:09 remaining.
An Eve Pyle layup tied the contest at 52-52 before Katrina Wheeler put Towson in the lead once more at 54-52.
Back-to-back layups by Little and Pryor gave DU a 56-54 lead with 1:59 left, but an Alis Freeman 3-pointer with 1:38 remaining regained the Tigers lead at 57-54.
TU extended its lead to three points after a pair of Baker-Brice foul shot with 28 seconds remaining. The Dukes miss a pair of shots on the next possession and had to foul Baker-Brice to stop the clock with eight seconds left.
Baker-Brice missed the first half of the one-and-one and the rebound was grabbed by Little, who immediately called a timeout.
The Towson defense clamped down and trapped Little in the corner off the inbound pass. Little got a pass off, but the time expired before the Dukes could get a shot off.
- This was the first-ever victory for Towson over Duquesne. The Tigers dropped the first five contests in the series.
- TU outscored DU 36-23 and out shot the Dukes 51.7 percent to 21.9 percent in the second half.
- 56 points is a season-low for the Dukes who averaged 81.3 points per game prior to today's contest.
- Towson outscored Duquese 38-26 in the paint and had 18 second chance points to DU's 12