Five Dukes scored in double figures - Kristi Little, Samantha Pollino and Keri Pryor had 15 points each. Eve Pyle recorded a season-best 11, all in the second half, and Alex Gensler added 10. Pryor also pulled down a team-best 10 rebounds to record her first double-double of the season.
The Flyers (13-6, 2-1) were led by Justine Raterman's 17 points, who was one of six UD players to score in double-digits.
With UD leading 73-68 with 46 seconds remaining in regulation, Little recorded her season-best eighth assist when she found Pollino all alone in the paint for a layup to close the gap to three points. Kayla Moses missed a layup on the ensuing possession and Pryor grabbed the rebound.
The Dukes called timeout with 23.4 seconds left to set up a play. Little's driving layup with 18 seconds got Duquesne within one point, 73-72.
Kendel Ross responded with a layup and was fouled on the play. Ross converted the 3-point play to give the Flyers a four-point lead with 12 seconds to play.
Little set up Gensler for a 3-pointer with five seconds to play to get the Dukes within a point at 76-75.
Duquesne immediately fouled Ross, who would convert 1-of-2 from the line to increase the Dayton lead to two points with three seconds left.
DU had to go the length of the court and could not get a shot off before the final buzzer as Flyers came away with the 77-75 victory.
The Dukes held an eight-point lead at the eight minute mark of the first half before the Flyers went on a 12-4 run over the next six minutes to tie the contest at 27-27.
Dayton scored the last three points of the half on foul shots to take a 30-27 lead into halftime.
The Flyers held Duquesne to 26.5 (9-of-34) percent shooting in the first half.
In the second half, Dayton came out of the gates on a 19-6 run, giving them their largest lead of the half, 16 points, at 49-33 with 14:31 to play.
DU chipped away at the lead as back-to-back 3-pointers by Pryor capped an 8-0 run to get the Dukes within one point at the 2:44 mark. However, the Flyers would not lose their lead.
- Dayton doubled up Duquesne in the paint, outscoring the Dukes 44-22
- Little was 10-for-10 from the foul line, continuing her streak of 23 consecutive foul shots
- Duquesne leads the all-time series 17-11.