On Saturday, East Carolina was able to get the game to within two points in the fourth quarter, but ultimately unable to complete a comeback and fell to the South Florida 38-22.
ECU only managed to put two field goals on the board in the first half and ended up going into the locker room trailing 17-6.
Most of the game after halftime would be led by backup quarterback Gardner Minshew, as starter Philip Nelson was knocked out of the game for the second straight week.
USF's lead would grow to 24-6 before the Pirates were able to get things rolling on offense.
A Minshew touchdown pass to Zay Jones, followed by a Plowman field goal, cut the lead to 24-16.
With 6:58 left in the fourth quarter, James Summers reached the end zone on a 3-yard touchdown run to cut the lead to just two, but the Pirates were unable to convert the two-point conversion that would have tied the game.
After letting the Pirates back in game, the Bulls woke back up and scored 14 unanswered points to put ECU away.
The USF offense was able to do just about anything they wanted to the whole game racking up 38 points and 556 total yards of offense.
Quarterback Quinton Flowers was a huge part of the Bulls' offense through the air and on the ground. Flowers threw for 250 yards and three touchdowns and added 115 on the ground.
In addition to Flowers, running back Marlon Mack rushed for 152 yards and two scores.
For the Pirates, Zay Jones had another tremendous outing with 18 receptions for 145 yards and one touchdown.
James Summers had a solid game as well rushing for 114 yards and a score.
With a short week ahead of the Pirates, Philip Nelson's health will be in serious question after being knocked out of the game in the third quarter.
The Pirates host Navy on Thursday night.