1. How does FSU defend the slot?
Former walk-on Javien Elliot has done a very good job over the last three games at the star position, but the athletes that Clemson has in the slot are on a different level from what he's seen so far. Artavis Scott leads Clemson in receiving yards this season, and most of his 514 yards have come on passes that he has caught within five yards of the line of scrimmage. Their other two slot receivers, Ray-Ray McCloud and Hunter Renfrow, have a combined 458 yards and 3 touchdowns this season.
2. Who plays QB for FSU and can they move the ball?
It looks like Sean Maguire is going to get the start for the second straight year against Clemson, but Florida State head coach Jimbo Fisher didn't rule out the possibility of Golson starting. Maguire did play very well against Syracuse, but this Clemson defense will be a much tougher task. If Florida State can move the football through the air they will be able to take some heat off the running game, which is always a good thing with a running back like Dalvin Cook ready to go.
3. Can FSU contain Deshaun Watson?
Watson is just as big of a threat running the football as he is throwing it. Watson is averaging 4.95 yards per carry, and has 4 touchdowns on the season. Florida State has done a very good job of containing mobile quarterbacks this season, and taking away Watson's ability to run would go a long way towards slowing down the high powered Clemson offense.
4. Can FSU run on the Clemson defense?
Clemson has one of the top run defenses in the country. They're currently allowing just 2.66 yards per carry to Power-5 opponents. That doesn't mean that Florida State won't be able to run. Dalvin Cook is a much better running back than any Clemson has faced this season. It will be very interesting to see if those numbers hold up against the Seminoles.
5. Can FSU stop Wayne Gallman?
Gallman is a battering ram at running back for the Tigers. He's averaging 5.5 yards per carry so far this season, and does most of his work after contact. The Seminoles have been very good against the run for most of the season, but they will have to be extremely physical at the point of attack to bring down Gallman.