Tailbacks Leon Washington and Lorenzo Booker will be held out as the pair continues to recover from injuries. Tight end Matt Henshaw is expected to play but did not practice Wednesday after tweaking a knee a day earlier during special team drills.
FSU could also be without starting tight guard Bobby Meeks, who continues to undergo a battery of medical tests and has watched the past two practices.
Meeks, who has been slowed by asthma, was taken to the hospital Monday night after experiencing chest pains during practice. Meeks suffered an asthma attack in Saturday's victory against Georgia Tech but returned to the game. Eric Broe has worked with the first team at tight guard.
"I went to the hospital Monday night, just trying to find out exactly what's going on," Meeks said. "We did agilities and I started getting dizzy. So, they sat me out but my (chest) started getting tighter and tighter.
"They've been running all kind of tests to find out what's going on. Heart, lungs, EKGs, all kind of blood tests. Everything you can imagine. I haven't been to class or anything. They got me trying to relax. I feel alright today, though I feel a little dizzy and my chest is a little tight."
Meeks' said his asthma attack Saturday was the first he has experienced in a game since high school. Physicians have changed Meeks' medication in hope to relieve the asthma, but to no avail. Meeks struggled with asthma attacks during the preseason as well.
Still, he hopes to be ready for Saturday's showdown against the Buffaloes.
"We were no-huddling (Saturday) and I didn't have a chance to catch my breath," Meeks said.
"Excitement, trying to get it done. I think I was just over anxious. I am preparing like I am going to play. If it's my decision, I am going to play. But it's up to the doctors, I have to listen to them."
FSU's offense, meanwhile, is looking for better consistency Saturday. The unit, which is averaging 410 yards per game, finally clicked in the fourth quarter of Saturday's victory. Quarterback Chris Rix directed the Seminoles scored two touchdowns in the final 7:09 to pull out the win.
FSU's running game sputtered against the smaller but quicker Yellow Jackets. Rix was the leading rusher with 41 yards. Greg Jones, in his third game back since tearing a knee ligament last November, was held to 22 yards on 14 carries.
Bowden said Wednesday that he doesn't want to rush Washington and Booker back into action too early. Washington is recovering from a dislocated right elbow sustained Aug. 30 against North Carolina. Booker continues his recuperation from a knee injury suffered against Maryland two weeks ago.
"No team stuff," Bowden said of Booker. "(We are) just trying to get his knee (strength) back. We are not going to play him unless he's perfect."
The Colorado defense, which was expected to be a strength of the team, is allowing 430.3 yards and 32 points per game, 99th and 93rd nationally in those categories. Of the 463 yards of total offense the Buffaloes allowed in last Saturday's loss, 310 came through the air.
Still, Bowden predicts a difficult game.
"They are more physical probably than any team we've played," Bowden said.