Quinn took over as the Florida defensive coordinator when Will Muschamp was named the head coach before the 2011 season. The two worked together for one season with the Miami Dolphins, and Quinn took over the defense in Gainesville while earning play-calling duties for the first time in his career.
In his second year as the defensive coordinator in 2012, the Florida defense was fourth in rush defense (94.9 yards per game), second in pass efficiency defense (95.5) and fifth in total defense (287.46).
Quinn's specialty in Gainesville was the defensive line. He helped develop players like Sharrif Floyd into an expected first rounder in April.