The Rebels used a pair of solo home runs in the second and fifth innings to give enough support for starting Holliman (8-2). The home run in the first was only one of two hits given up by Florida starting pitcher Tommy Boss (3-4) in the first four innings.
Boss would take the loss as he lasted 5 2/3 innings and gave up seven hits and three runs with one walk and four strikeouts.
His counterpart on the mound would pitch 127 pitches over his 7 2/3 innings. Holliman would give up nine hits and two runs with a pair of walks and seven strikeouts.
In the second Brian Pettway went the other way with a solo shot for his fourth home run of the season. Alex Presley provided the long ball punch as he hit solo shot in the fifth for the Rebels 2-0 lead.
Holliman kept the Gators at bay for the first half of the game, giving up just two hits to Jonathan Tucker and C.J. Smith in the first five frames.
Boss would get knocked out of the contest in the sixth after giving up a two out double to Charlie Babineaux that scored Pettway to extend the Ole Miss to 3-0. Pettway had walked and advanced to second on an Alex Presley single. Connor Falkenbach would come in to put out the fire, getting Matt Tolbert to ground out to end the inning.
The Rebels would tag on another run for the third consecutive inning in the seventh off of a RBI single by Chris Coghlan that scored Barry Gunther from third. Gunther led off with a double and advanced on a sacrifice bunt by Cooper Osteen.
UF made a charge late in the game as Brian Jeroloman, Brian Leclerc and C.J. Smith each had base hit in the eighth inning to load the bases for Ben Harrison. Harrison hit a RBI infield single to make it a 4-1 game, which also forced Holliman out of the game.. Corsaletti followed suit as he hit a RBI single to right to cut the lead in half. The rally ended as Matt LaPorta popped out to first base.
Florida would hold Ole Miss to just the four runs as relief pitcher Steven Porter came on to shutdown the Rebels. Porter threw 2 2/3 scoreless innings and struck out two.
Smith and Harrison each went 2-for-4 while Leclerc also had a pair of hits and scored a run.
Game two of the series will start tomorrow at 4 p.m. ET. The Gators will send RHP Justin Hoyman (10-0) to the mound to face Rebels RHP Anthony Cupps (2-2).
Florida's five hits in the eighth equaled what they had the previous seven innings.
The game time of 2:52 was the 37th time this season that Florida played a contest that was under three hours.
The Gators pitching staff has only allowed 13 walks in the last 11 games.
Florida did not commit an error in a game for the ninth time this season.
The multi-hit game for Smith was his team leading 22nd of the season.
Florida dropped to 4-5 on Friday night SEC games.