Trent Johnson's worst nightmare became a reality just 12 seconds into the game.
TCU's leading scorer Amric Fields' knee buckled on a shuffle cut leaving Fields on the court writhing in pain.
In a non-contact injury, Fields left knee buckled to the floor, likely ending the junior's season.
TCU head coach Trent Johnson choked up as he said, "Without hearing the doctor's report, I have to believe he's done."
Johnson knew when he took the job at TCU that he had a difficult job ahead of him, but the job is now even tougher.
Shaken after the injury, SMU jumped out to an early lead, and TCU never led.
"[Amric] was a big loss, but we had to get over it real quick. A lot of younger guys have to step up to the plate right now. I wish him the best, but we have to move on," Jarvis Ray said.
However, the jump shooting of Jarvis Ray and Garlon Green kept the Frogs in the game until the end. Green and Ray finished with 20 and 14 points respectively.
Jones then missed two free throws as well, but Kyan Anderson's three-point attempt at the buzzer was blocked.
TCU outshot the Mustangs on the night. The Frogs shot 49 percent from the floor compared to just 44 percent for SMU, but SMU converted TCU turnovers into 27 points.
"I just think we turned the ball over too much, and we didn't get enough 50/50 balls. They hurt us," senior Garlon Green said.
Jarvis Ray has seen marked improvement in his game under first year head coach Trent Johnson.
"I have a chip on my shoulder right now," Ray said. "I've been sitting out, and I have to come back way stronger than I did last year and my freshman year. I have a big role right now, so I'm taking advantage."
In addition to Ray's 14 points, he also had three assists and drew three charges in the second half.
TCU's next game is against Prairie View A&M who was picked to win the SWAC this year.
"We'll come back out tomorrow. Prairie View is a similar team to SMU, and they are favored to win the SWAC Conference," Trent Johnson said. "It's going to be a tough matchup for us Sunday, but we have to get two good hard days of practice and move forward."