Indiana kept knocking on the door but had a difficult time reaching the end zone.
Ohio State did it with ease.
Both players scored a pair of touchdowns on the ground, with Miller adding two through the air.
Ohio State outgained Indiana by just 29 yards (471-442) but made a ton of big plays. The Buckeyes took the opening possession and marched 71 yards in five plays to go up 7-0.
Miller broke off a 41-yard run to set up a 16-yard rushing touchdown by Hyde two plays later.
Ohio State ran for 311 yards on 39 carries, a robust eight yards per carry.
Miller did his damage through the air in the second half. He tossed touchdowns of 24 and 39 yards to put Ohio State up 42-0 and far out of reach early in the fourth quarter.
Indiana had its chances to stay close to the Buckeyes but couldn't capitalize when it got into Ohio State territory.
IU got to the OSU 25 before the drive stalled. Mitch Ewald's 42-yard field goal attempt hit off the right upright. It was his first miss of the year.
Indiana's offense got into Ohio State territory on five straight possessions starting late in the second quarter through early into the fourth quarter, but failed to score.
Indiana was 7-for-21 on third down and 5-for-8 on fourth down.
Look for more coverage later tonight.