Iowa State drove into Oklahoma territory on each of its second-quarter drives. Grant Mahoney followed up with a miss on a 45-yard field goal attempt and his 50-yard field goal attempt as time expired in the first half was short.
In the second quarter, Oklahoma wide receiver Ryan Broyles split two Iowa State defenders and caught a 39-yard TD pass from Jones that had put the Sooners up 17-0 with 13:06 left in the first half. OU's seven-play, 59-yard drive made it 24-0 with 4:29 left in the second quarter. A final TD just before the end of the half gave the Sooners a 31-0 lead at halftime.
Iowa State freshman Kirby Van Der Kamp averaged 49.1 yards on eight punts while placing three kicks inside the 20-yard line. Van Der Kamp had three punts of 60 yards or more.
David Sims had a career-high 16 tackles for the Cyclones. Jake Knott and A.J. Klein finished with 13 tackles each.
Collin Franklin tied a career-high with six receptions for 34 yards. Jake Williams had a season-high 51 yards on three receptions.
Iowa State plays at Texas Saturday at 11 a.m. in Austin, Texas.