After an Austin Flynn-dominated drive to start the game stalled after one first down, Oklahoma took over at its own 38-yard line. Although very efficient throughout much of their possession, the Sooners hit the red zone and couldn't make the plays. Renaldo Works rushed three times for 22 yards and Jason White completed 3-of-4 passes for 30 yards.
However, an illegal procedure penalty on 3rd-and-2 at the 10 would lead to a 33-yard field goal by Trey DiCarlo with 8:37 left in the quarter.
Although its offense would not hold up its end of the deal, ISU's defense held firm against the Sooners. After DiCarlo's kick made it 3-0, the Cyclones held OU to consecutive three-and-outs and Works to just four yards on three carries.
ISU's offense was just as stagnant, however, and couldn't get much going outside of Flynn. Michael Wagner provided the only sizeable gain on the ground, rushing outside for 15 yards on a first down play.
Some big plays through the passing game gave the Sooners a spark to begin the quarter. White connected on pass plays of 21, 18, 13 and 15 yards to put his team up 9-0 with 9:53 left in the half. His 15-yard completion to Jejuan Rankins capped a 79-yard scoring drive, however, DiCarlo missed the extra point.
Talk about a bad turn of events for ISU, a Jack Whitver fumble on one play turned into a Sooner touchdown on the next. Flynn stepped up and hit Whitver for a big gainer near midfield, only to have the receiver cough it up after being hit from behind. On the ensuing play, White hit Mark Bradley for a 39-yard touchdown and 16-0 lead with 4:33 left in the half.
A Cyclone three-and-out would lead to another Sooner score shortly before halftime. White hit on four consecutive passes for 61 total yards, including a strike to Mark Clayton from the 24. However, the two-point conversion pass failed and Oklahoma had to settle for a 22-0 edge with 28 seconds left in the half.
Flynn's first interception of the evening proved costly for ISU early in the half. His long pass down the left sideline caught too much air and was picked off by Brodney Pool at the Sooner 33. Four plays later, Oklahoma made it 29-0 on a 45-yard screen pass from White to Peoples. The long score came after numerous Cyclone defenders missed tackles as the OU receiver danced down the left sideline.
Taking over at their own 17-yard line, the Sooners drove the length of the field eating up chunks of yardage only to be stood up near the goal-line again. A holding call on a White-to-Clayton connection wiped out what would have been another long touchdown play, and OU ended up settling for a 22-yard field goal from DiCarlo.
ISU's offense was non-existent throughout much of the session, going three-and-out twice and seeing another drive end on third down with Flynn's interception.
The Sooners added another touchdown early in the fourth quarter when White connected with Clayton in the middle of the end zone. The score made it 39-0 with 12:18 remaining.
ISU finally found the end zone early in the quarter, as its points came courtesy of a JaMaine Billups interception and 77-yard return on a quick pass from White to the right. Billups scamper into the end zone cut the deficit to 39-7 with 10:48 remaining to play.
However, OU quickly erased the score on a 100-yard kickoff return from Mark Bradley 14 seconds later, making it 46-7. Donta Hickson tacked on a five-yard scoring run with just over one minute to play, accounting for the final tally of 53-7.