Although it picked up a first down on two Stevie Hicks rushes, Iowa State was forced to punt. Colorado took over at its own 31-yard line and didn't waste much time marching into Cyclone territory. The Buffaloes got a couple of nice pass plays to Derek McCoy on 2nd-and-long and 3rd-and-long for a fresh set of downs. Then, after a Joel Klatt quarterback sneak on 4th-and-short, D.J. Hackett hauled in a 42-yard touchdown pass to make it 7-0 at the 8:25 mark.
After netting 19 yards on their first three plays, the Cyclone offense went south in a hurry. In fact, their yardage was negative-eight over the next three drives. Colorado, meanwhile, would end up scoring on its first three drives. Freshman Daniel Jolly would give his team a 14-0 lead on a two-yard touchdown with 2:18 left in the opening quarter.
ISU would get a first down on the ensuing drive, but only when a Colorado cornerback interfered with Lane Danielsen on a pass near the left sideline. However, a false start penalty and sack of Waye Terry quickly ended any ISU hopes of sustaining a drive.
After a nice return from Jeremy Bloom, the Buffs got great field position and needed just four plays to go 28 yards for another touchdown. This time it was Brian Calhoun going in from four yards out, making it 21-0 just 1:45 into the second quarter.
Colorado's dominance continued throughout the second quarter. Klatt would hit a wide open John Donahoe for a 20-yard touchdown to make it 27-0, then kicker Mason Crosby booted a 26-yard field goal just under two minutes later. After a fumble by Stevie Hicks on an ill-advised screen pass, Colorado tacked on another touchdown on a four-yard run by Calhoun.
Finally, after more than 162 minutes of offensive futility, the Cyclones snapped its scoreless drought when Adam Benike booted a 31-yard field goal with 10:32 left in the third quarter. The field goal came after a couple of nice passes by Waye Terry, which included a 10-yard strike to Lance Young with put ISU in field goal range.
Although the Cyclones would win the first 8:24 of the second half, that edge would come to a close when Colorado converted on an 80-yard scoring drive. On the 10th play of the lengthy march, fullback Lawrence Vickers plunged in from a yard out, making it 44-3 with 6:36 remaining in the session.
After ending its scoreless drought in the third quarter, ISU put an end to its run of zero touchdowns when Terry hit Jamaul Montgomery for a 28-yard touchdown pass. Unfortunately, CU still led by a 44-10 margin with just under 12 minutes to play.
The Cyclones looked ready to cap off their most impressive scoring drive in weeks when Hicks dashed into the end zone from the four-yard line. But the touchdown was called back for ISU having 12 players on the field. That was as close as ISU would get to the end zone. Four plays later, the Cyclones turned it over on downs after coming up short on 4th-and-26.