Despite shooting 52 percent from the floor in the first half, Iowa State owned just a four-point edge at the half (30-26) thanks to five Indiana 3-pointers. The Hoosiers were held to 30.4 percent accuracy in the first stanza.
Indiana (2-2) got a layup from Jamey Chapman at 18:17 in the second half to narrow the gap to 31-28, but the Hoosiers would fail to score for over four minutes, giving Iowa State a 14-0 run and a lead the Cyclones would never relinquish.
Iowa State led IU on the boards 34-30 and forced 19 Hoosier turnovers. Indiana, led by Cyndi Valentin's 17 points, shot 33.3 percent for the game.
The Cyclones return home to face instate rival Iowa Wednesday in Ames and then travel to Wisconsin Dec. 7 for their third consecutive game against a Big Ten Conference team.