Iowa State's defense made the first big play of the day on the opening drive, when Jamarr Buchanan picked off a Brad Smith pass on 3rd-and-7. Outside linebacker Erik Anderson tipped the pass and Buchanan secured it at the Tiger 35-yard line. However, the Cyclone offense would go four-and-out into a stiff wind and turn the ball back over at the Mizzou 35-yard line.
Much of the opening quarter saw was a field position dual, with opposing offenses neutralized because of the frigid temperatures. ISU came up short twice on 4th-and-1 attempts, and turned over possession without the benefit of a punt. The Tigers didn't do much better, and were stopped on a few three-and-outs.
Mizzou took over the momentum clearly midway through the second quarter by putting together a nine-play, 94-drive that lasted just under four minutes. Much of the work was done by backup tailback Marcus Woods, who rushed three times for 35 yards, including the five-yard scamper into the end zone. Woods' score put the Tigers up 7-0 with 5:38 remaining in the half.
The Cyclones, despite being penalized for an illegal block on the kickoff, were able to move the ball courtesy of a 23-yard reverse run by Jon Davis on first down. After a pair of incomplete passes by Meyer brought up 3rd-and-10, the redshirt freshman quarterback hit Todd Miller for 27 yards to move the chains. Two plays later, Meyer kept on an option play and scored from 13 yards out. Bret Culbertson's PAT tied the game at 7-7 with 4:09 left in the half.
After a three-and-out by Mizzou, the Cyclones, taking over at their own 41-yard line, had the opportunity for another score. Meyer hit a diving Miller for 13 yards on 3rd-and-6 to set his team up in Tiger territory. However, Missouri's pass rush picked up on the following three plays and forced two incomplete passes and a sack of Meyer. Troy Blankenship was brought in to punt with under a minute left.
Missouri struck first in the second half by getting a big run from Brad Smith at the 5:48 mark of the quarter. Steve Paris came through on the blitz and the Tigers gashed them with Smith's 36-yard run up the middle. The score and PAT put the Tigers up 14-7 with 5:48 left in the third quarter.
ISU suffered a big blow when Bret Meyer was injured early in the quarter. Reserve quarterback Austin Flynn came in, but the offense stalled even worse than it already had. Flynn faced a constant rush and was sacked for a seven-yard loss on 3rd-and-11 to bring out Blankenship.
In need of a big defensive stop, the Cyclones got it by forcing Mizzou three-and-out near midfield. But after a punt, ISU got the ball back with a long field to deal with.
The defense came up with one more big stop to give the offense a shot to tie the game. This time, Meyer and company answered the call. Meyer hooked up with Todd Blythe for 35 yards on the opening play to set the Cyclones up at the Tiger 27. Meyer rushed for 15 yards on the following play to put his team in the red zone. Another fresh set of downs followed with Davis' 10-yard reverse run. Hicks then capped off the drive with a two-yard touchdown run, making it 14-14 with 8:58 to play.
ISU had a golden opportunity to take the lead in the waning moments after another big fourth-quarter turnover by the defense. Steve Paris picked off a Smith pass in Cyclone territory and returned it to the Missouri 15-yard line. After three Hicks carries that netted nine yards, Culbertson was called upon to attempt a 24-yard field goal. However, the kicker missed just his second attempt of the season wide right.
Missouri took over at the 20-yard line and ran out the clock.
Missouri opened the overtime with a 24-yard field goal from Joe Tantarelli. ISU took over possession and got a pair of first down plays to set up 1st-and-goal inside the four. Meyer hit Davis for 11 yards and a first down, then handed off to Hicks for another fresh set of downs. However, on 3rd-and-6, Meyer lofted a pass for Davis in the end zone and it was picked off by the Tigers, icing the 17-14 victory.