The Cyclones closed out their nonconference schedule with a 10-1 record, a seven-game win streak and a perfect home record (7-0). ISU collected two tournament titles, winning at UNLV's Duel in the Desert and its own Cyclone Classic.
After trading baskets to start the game, Iowa State steadily built a lead and never looked back. ISU owned a 48-31 halftime lead after shooting 48.6 percent from the floor. The Cyclones got 13 points from Katie Robinette in the first half and owned 15 on 17 baskets made. Lyndsey Medders turned in 10 of ISU's 15 first-half dishes, already a career best.
Iowa State finally hit an offensive groove in the second half, sinking 55.6 percent overall and 53.8 percent from behind the arc. The Cyclones outscored Murray State 23-6 in less than five minutes, sinking 8-of-10 shots to own their largest lead of the game at 89-55.
Medders finished with 13 assists for a double-double, following a traditional double-double performance (16 points, 10 rebounds) in ISU's first-round game. O'Neil hit a career-best five 3-pointers en route to her game-high 24 points, including a perfect 4-of-4 second-half performance from behind the arc. Robinette sank all four of her second-half shots and drained her first trey of the season in the first stanza.
The Cyclones finished the game with 27 assists on their 32 baskets and outrebounded the Lady Racers 47-30. ISU's Brittany Wilkins pulled down a season-high 10 rebounds in 13 minutes of action. Iowa State held MSU to 34.3 percent accuracy while shooting 51.6 percent from the floor for the game.
Murray State, now 4-6 overall, got 21 points from Rebecca Remington and 11 from Ashley Hayes. Remington earned all-tournament accolades along with Mercer's Jessica Miller and Eastern Illinois' Pam O'Connor.
Iowa State opens Big 12 Conference action playing host to No. 22 Kansas State Jan. 5 at 7 p.m.