The Cyclones (11-8, 4-4 Big 12) held a 25-20 lead in the fourth game but the Aggies stormed back, scoring 10 of the final 12 points to clinch the game and match.
"I am not disappointed in the way we played [Wednesday] night because I thought that we played as well as we have all season at some points," said head coach Christy Johnson. "Texas A&M just played very well and seemed to get the big points at key times in the match. That was the difference."
The Cyclones took a 1-0 lead in the match with an impressive 30-18 win in the first game, behind a team hitting percentage of .387.
ISU used a 4-0 run to distance them from the Aggies and go ahead 15-8 in game one. Boeve had five first game kills and the Cyclones went on to the win.
The second game saw Texas A&M win in thrilling fashion, 36-34. The game was tied 20 times and featured eight lead changes. A kill by A&M's Christi Hahn put the Aggies up 35-34 and an attack error by the Cyclones tied the match up at one game apiece.
A&M controlled the third game from the start, hitting .361 on its way to a 30-25 lead. The Cyclones hit just .194 in the game and the Aggies' Laura Jones had six kills in the game to pace Texas A&M.
The Cyclones' were unable to fend off the Aggies after leading by as much as five twice in the game. Kelly Stanton had six kills in 11 attempts to help A&M clinch the match.
Iowa State's Katie Jessen posted a double-double with 12 kills and 10 digs and Amanda Craig had 49 assists and a season-high 16 digs in the loss.
Jones led the Aggies with 22 kills and Hahn chipped in 18 to lead Texas A&M to their second straight Big 12 win after opening the Big 12 with five losses, four of which came at the hands of ranked teams.
The Cyclones will face Oklahoma on Saturday in Norman, Okla. First serve is slated for 3 p.m.