Iowa State (7-6) pounded out 11 hits while limiting Charleston Southern (4-15-1) to just four hits. The Cyclones have held their last four opponents to four hits or less en route to winning five straight games for the first time since 2003.
With the Cyclones leading 3-1 in the bottom of the second, Killeen drilled a Jill Shondel pitch over the wall in left center to pick up the second grand slam of her career and increase the Cyclone lead to 7-1.
The Cyclone lead was 9-1 after Killeen struck again with a fourth inning two-run shot. After Iowa State added another run, Katherine Cross grounded out to shortstop to score Jessica Quade and give the Cyclones an insurmountable 10-run lead.
Alyssa Ransom (3-3) went the distance for ISU and allowed one run on four hits to pick up the win.
Ellen Buehner joined Killeen with a pair of hits in the game.
With the win, the Cyclones earned a first round bye in
bracket play and will face the winner of the Charleston Southern/UNC Greensboro
game at 10 a.m. Sunday.