Ford (7-5) was dealt the loss despite tossing a complete game five-hitter and striking out 11 Flames in the game. It was the fifth game this season that Ford has recorded 10-plus strikeouts.
Liberty (19-7) touched the scoreboard for a pair of solo runs in the fourth and fifth innings to jump out to a 2-0 lead.
Beth Hensley started the scoring with a double to left center that plated Ashley Williams and put the Flames ahead for good. Liberty would add another in the next frame on a single by Dawn Jeffs that made the margin 2-0 in favor of the designated visitor.
That would be all the scoring Iowa State would get as Sarah Swor (8-3) shut the Cyclones down in the seventh inning. Swor allowed five hits in the contest.
The Cyclones squandered a scoring opportunity in the first when Killeen and Katie Reichling reached on a pair of back-to-back two-out singles. A strong throw from Hensley, the leftfielder, on Reichling's hit got Killeen at home to end the inning.
Killeen went 2-for-3 with the lone RBI to lead Iowa State in the loss. Reichling also collected a pair of hits.
The Cyclones will face Liberty again on Sunday at 10 a.m.