Missouri clinched itself a share of the Big 12 North Division title and a trip to the Big 12 Championship Game in Kansas City on December 6, while Iowa State dropped its ninth straight on a night where 19 Cyclone seniors played their final game at Jack Trice Stadium.
"It hurts to lose. You look at this conference up and down and the Big 12 is just stacked this year," quarterback Austen Arnaud said. "We all can fight and we all can put up points. To see where this conference is at this year compared to others is mindblowing."
Clock-eating drives were the way to go in the first quarter, as Missouri possessed the ball twice and Iowa State only had it once. Jeremy Maclin returned the opening kickoff to the Tiger 41 and Missouri took 11 plays and five minutes to score their first touchdown, a pass from Chase Daniel to Tommy Saunders from three yards out.
"We really didn't do a nice job stopping (Daniel) all night. I think the difference in the game obviously was that we couldn't get off the field on third down," coach Gene Chizik said. "We gave up too many plays, and with Chase, he is going to put the ball about where he needs to put it every time.
The Cyclones moved the ball down to the Missouri 20 on the next series but Alexander Robinson was stopped on fourth and one. The Tigers used their dangerous short passing game once again to drive the ball right down the field and scored on a two-yard run by Derrick Washington.
"We wanted to hold onto the ball, that was our gameplan," Robinson said. "We wanted to go a little bit longer, go on long, sustained drives and try to keep their offense off the field."
Iowa State then punted and Missouri got the ball on its own 41 but Allen Bell intercepted Daniel at the Tiger 10. Three plays later, however, William Moore intercepted Arnaud and took it 17 yards to the house to make it 21-0.
The Cyclones got on the board on their next series, taking the 73 yards on 11 plays. Arnaud hit Patrick Neal from one yard out to make it 21-7 but Washington went 52 yards to paydirt on the next Missouri series to re-extend the lead to 21. Iowa State was stopped on downs at its own 48 on its next series and Missouri got a field goal as time expired in the first half to make it 31-7.
Despite struggling a bit in the first half, Iowa State got on track to open the second half, driving down for a 47-yard Grant Mahoney field goal. The Cyclones got another field goal from Mahoney after Leonard Johnson recovered a Maclin fumble with Missouri going in for a score.
"That's why I'm very proud of our team they were talking about keep playing and keep fighting on the sidelines," Chizik said. "Offensively I think our guys kept fighting back."
Daniel hit Maclin for a 43-yard strike on the next series but Arnaud responded right back, hitting Collin Franklin from 25 yards out to make it 38-20. Missouri was able to turn another big Maclin, who had 255 all-purpose yards on the night, return into a Jimmy Jackson two-yard touchdown run on the next series, though.
Iowa State continued to move the ball, driving into the red zone on the next series, but Arnaud was picked off in the endzone while taking a big hit. The Tigers turned that into another Jackson touchdown run to cap the scoring, even though Iowa State nearly scored one more time late.
Iowa State was able to keep the yardage battle tight at 497-444 and won the time of possession battle, but Daniel, who threw for 328 yards and two touchdowns, and his multitude of targets proved too powerful. Arnaud threw for 326 yards and two touchdowns, but