Wecker went 10-of-17 from the floor, including 4-of-5 from 3-point range. Nicole Ohlde held the previous record of 39 career double-doubles.
Kansas State (9-2) won its fifth straight and improved to 67-1 when scoring at least 70 points. The loss was the seventh straight for Central Connecticut State (1-8).
Laurie Koehn added 15 points on 5-of-9 shooting from 3-point range.
The Wildcats led 29-16 at the half before outscoring the Blue Devils 48-7 in the final 20 minutes. Kansas State finished the game on a 31-1 run.
Twiggy McIntyre finished with 14 points for Kansas State.
Brittney Dixon led Central Connecticut State with eight.