Wecker, who hit the 25-point mark for the ninth time this season, connected on 12 of her 23 attempts from the field and was the only Wildcat to finish in double figures. Her 29 points marked a new Big 12 Conference game career-high. The rest of the team struggled from the floor, making a combined 11-of-30 shots as Kansas State (17-5, 8-3) dropped its second-straight on the road.
Meanwhile, Oklahoma (13-9, 5-6) was having its way from beyond the arc, drilling 9-of-16 treys. Four Sooners finished in double figures, led by Dionnah Jackson's 18 points. Laura Andrews and Chelsi Welch, who were each 3-for-3 from 3-point range, finished with 15 and 14 points, respectively, while Leah Rush added 12.
Oklahoma used a 19-4 run late in the first half to take control of the game, then sprinted out of the gates in the second and put the contest on ice.
The Sooners led 41-31 at intermission, then outscored the Wildcats 24-10 during the first eight minutes of the second half to build a 65-41 advantage with 12 minutes to play.
The Wildcats were able to pull within 12 at 69-57 with 6:22 on the clock but were unable to get any closer as the Sooners held on for their second straight win over K-State.
Kansas State actually started the game on a roll, scoring 12 of the contest's first 15 points and leading by as many as nine in the early going.
But Oklahoma responded with a 14-4 run that gave the Sooners their first lead at 17-16 with 12:33 to go in the first. A 3-pointer by Chelsea Domenico put the Wildcats back on top for the final time with just over 11 minutes remaining in the period as K-State went scoreless for the next 3:44.
By the time Wecker connected on a pair of free throws at the 7:26 mark, OU was on top to stay.
Kansas State will look to bounce back on Wednesday night at Bramlage Coliseum, when the Wildcats host No. 17 Texas (15-7, 8-3) for a 7 p.m. tipoff.