McCray, who had been struggling from beyond the arc (five of 19 over five games), led all scorers with 25 points, thanks to six of seven shooting from long-distance. She also grabbed ten rebounds.
Mosley, who had a field day taking her defenders off the dribble, came within an assist of recording a triple-double with 21 points, 14 rebounds and nine dishes.
"Defensively we didn't answer the aggressiveness and attack that Kansas brought to the floor particularly from their perimeter," K-State coach Deb Patterson said.
"When it came to making really big plays, really big baskets, KU stepped up and we didn't step up at the same level they did and I felt that was the difference in the game."
McCray and Mosley had several big shots throughout the contest, but their biggest baskets came during the two overtimes.
Mosley scored eight points in the first OT, including four in the final 20.3 seconds, to knot the game up at 70.
K-State, now 16-10 overall and 4-9 in the Big 12, however, did have a great opportunity to extend its winning streak at the end of those extra five minutes, but couldn't sink its free throws; an aspect of the game that really haven't been much of a concern to Patterson all season long. The Cats shot 55.2 percent (16 of 29) from the stripe.
Kansas, 9-17 and 3-10, rode that momentum into the second OT outscoring the Cats 12 to four. McCray hit a pair of three pointers to seal the victory and for the first time in a very long time the loyal crimson and blue fans finally got to chant Rock Chalk Jayhawk with K-State in the building.
"It feels good to win," Kansas coach Bonnie Henrickson said.
"There are a lot of people who have been around for the streak longer than I have certainly and you appreciate that for them and you appreciate it for the these kids. The mentality and the confidence that the young kids play and bring, they don't know about the streak, it doesn't matter to them. It matters to play well and win."
Wildcat freshman forward Ashley Sweat paced the team with a career-high 20 points and seven boards. The McPherson, Kan., native helped lead the Cat charge in the second half and sent the game into overtime with a basket in the paint.
The Jayhawks dominated the Cats on the glass outrebounding them 50-39. In fact, Kansas State has been out-rebounded in all but two contests (both against Colorado) since the loss of starting forward Marlies Gipson, who injured her knee Jan. 15 and then re-injured it during warm-ups before the Feb. 3 contest against Texas.
Up next for K-State is Missouri on Wednesday in Columbia. The Cats beat Mizzou 81-66 last month in Manhattan, but will have to find an answer in the paint against the Tiger's big post EeTisha Riddle or at the very least make a few more free throws.