He muscled-up to 245 pounds to be a power-forward in 2006-07, and slimmed to 225 for the 2007-08 season when the 6-foot-5 senior was penciled in as a preseason off-guard.
As a Wildcat sophomore, Hoskins made the league's all-Newcomer team, and as a junior he was selected second-team all-Big 12.
Now, Hoskins has hit the wall. A knee surgery in August, and after acknowledging that he came back too quickly, another knee surgery in early-November has sidelined him through the first nine games of the season.
It led coach Frank Martin to say last week, "He's in God's hands."
Some close to the program say that Hoskins will be back; others just as close say he's out for the season. He's been seen showing bounce and agility while working out with a trainer, but he is not going through regular practices.
While Hoskins hasn't been allowed to speak to the media, his father, Daryl, said, "He's devastated. It's probably the worst experience of his life."
Hoskins has been the picture of stability in the Wildcat program averaging 13.1 points and 4.5 rebounds as a sophomore, and 14.5 points and 5.9 rebounds as a junior.
With a cast of outstanding freshmen around him, he's exactly what the program needed heading into the season.
"The one thing we desperately miss is his leadership," Martin said. "He was the most outspoken person in the locker room last year, and he probably would have been the most outspoken person in the locker room this year. If I'd tell you we would not be better with him, then I would be lying to you."
But Martin, who says he's had five knee surgeries himself, says that Hoskins will not be rushed back into duty.
"That knee's got to heal up the right way," Martin said. "He doesn't need to be waking up and feeling like I do. He doesn't deserve that. He deserves an opportunity to play beyond college. The knee has to heal up the right way for that to happen."
But that leads to another question. If Hoskins has a future in basketball, likely in Europe, should he make the move after the season as a 22-year-old, or try to get an extra year from the NCAA and return to the Wildcats for the 2008-09 season as a 23-year-old?
"Right now, it's up in the air," Daryl Hoskins said. "He'd love to play. He was ready to compete his senior year. He's never had a serious injury like this. David probably would hobble out there if he could but he knows he shouldn't."