Freeman was 21-of-28 for 272 yards and has 6,238 career yards to eclipse Lynn Dickey for No. 1 all-time on the Kansas State list. With 35 touchdowns passes, he's two short of Ell Roberson's school record.
Freeman, a 6-foot-6, 250-pound junior who has started every game since his freshman year, also ran for two TDs. He threw TDs of 12 and 3 yards to Deon Murphy in the first half and connected with Brandon Banks on a 53-yard scoring play that made it 42-23 with 1:49 left in the third.
But the Cajuns (1-3) and Tyrell Fenroy, who had three touchdowns and 183 yards rushing, were not done. The Wildcats (3-1) needed a trick play on fourth down and a key third-down pass by Freeman to hold the ball for more than 7 minutes and kick a field goal with 1:37 left to preserve the win.
Right after Banks' TD, Fenroy broke loose on a 69-yard touchdown gallop. Then halfway through the fourth quarter Fenroy's 1-yard scoring run sliced the margin to 42-37.
Fenroy also had 12 yards receiving, pushing his career total in rushing and receiving to 4,182 yards. It was the 19th 100-yard rushing game for Fenroy, who became the first Cajun with more than 4,000 combined yards rushing and receiving.
The Cajuns looked like they would get the ball back with plenty of time to try for the winning TD. But for the second week in a row, Kansas State snapped the ball directly to Tysyn Hartman on a fake punt and he ran 4 yards on fourth-and-two. On third-and-six with 3:15 left, Freeman hit Banks with a 17-yard pass, and Brooks Rossman kicked a 26-yard field goal for the final margin.
Lamark Brown, a wide receiver, started at running back for Kansas State and had 137 yards, including a 3-yard touchdown that put Kansas State on top 35-17 in the third quarter.
Freeman scored on runs of 7 and 15 yards in the 21-point second quarter.
Murphy's touchdown reception made it 28-3 before the Cajuns closed out the half with Fenroy's 15-yard touchdown run.
Louisiana-Lafayette scored just 18 seconds into the second half after recovering Freeman's fumble. Wide receiver Richie Falgout, on an apparent end-around, pulled up and flipped a 28-yard scoring pass to Jason Chery.
Brown's 3-yard run made it 35-17 in the second half before Desormeaux's 1-yard run cut the lead to 35-23.