J.T. Tiller added 15 points, six rebounds and six assists and Leo Lyons and reserve Lawrence Bowers both had 16 points for the Tigers, who have won seven straight since losing 88-72 to the Wildcats in Manhattan, Kan., on Jan. 28.
Missouri (24-4, 11-2 Big 12) trailed by 13 points at halftime in the first meeting and led by 23 points at the break in the rematch.
Denis Clemente scored all but 11 of his 33 points in the second half for Kansas State (19-9, 7-6), which shot 37 percent with 21 turnovers and got eight points from Jacob Pullen, who had 23 points in the first meeting. The Wildcats trailed by a season-worst 32 points in the second half and also hit program lows for points allowed in a half (55) and overall.
The Wildcats, who had won seven of the last nine games in the series, got as close as 16 points in the second half before Missouri pulled away again.
Missouri led 55-32 at halftime as Matt Lawrence was 3-for-3 from 3-point range, while Tiller and reserve Lawrence Bowers had 10 points. Bowers was 5-for-6 from the field over the last 3:12, including an alley-oop dunk from Miguel Paul and two putbacks in the final 6 seconds.