J.T. Tiller added 15 points, six rebounds and six assists and Leo Lyons and reserve Lawrence Bowers both had 16 points for the Tigers, who have won seven straight since losing 88-72 to the Wildcats in Manhattan, Kan., on Jan. 28.
Missouri (24-4, 11-2 Big 12) trailed by 13 points at halftime in the first meeting and led by 23 points at the break in the rematch, embarrassing a team that has lost only twice in its last 10 games.
Missouri entered the game averaging 87.4 points and with a 26.5-point margin of victory at home this season. Big 12 play hasn't been much of a challenge either, with a 21.5-point margin of victory entering the Kansas State game with the lone exception a two-point thriller over No. 15 Kansas on Feb. 9.
Denis Clemente scored all but 11 of his 33 points in the second half for Kansas State (19-9, 7-6), which shot 37 percent with 21 turnovers and got eight points from Jacob Pullen, who had 23 points in the first meeting. The Wildcats trailed by a season-worst 32 points in the second half and also hit program lows for points allowed in a half (55) and overall.
The Wildcats, who had won seven of the last nine games in the series, got as close as 16 points in the second half before Missouri pulled away again.
The Tigers matched their best victory total from the last 15 seasons, a 24-12 record by the 2001-02 team, with three regular season games to go. They reached 11 conference wins for the first time since 1998-99 and the seven-game Big 12 winning streak matches the school's best from 1999-2000.
Missouri led 55-32 at halftime as Matt Lawrence was 3-for-3 from 3-point range, while Tiller and reserve Lawrence Bowers had 10 points. Bowers was 5-for-6 from the field over the last 3:12, including an alley-oop dunk from Miguel Paul and two putbacks in the final 6 seconds.
Missouri converted 11 turnovers into 15 points while allowing no points on its three turnovers. The Wildcats shot 35.5 percent and were 2-for-10 from 3-point range. It was Kansas State's deepest halftime deficit by far, previously trailing Kentucky by 14 on Nov. 28 in a two-point loss.