Darius Miller added 15 points for Kentucky (2-0). The Wildcats scored the first 15 points, with Portland native Terrence Jones hitting a 10-foot jump hook for the first basket and Miller scoring seven straight.
Eric Waterford led Portland (3-1) with 12 points.
Portland had a 13-8 run, including eight points by Waterford, to cut it to 23-13 with 7:20 left in the half. But Kentucky responded with eight straight to make it 31-13.
The Pilots did manage an 11-7 spurt to end the half at 38-24, but Kentucky opened the second half with a 12-2 run that pushed the Wildcats' advantage to 24 at 50-26.
Another big run - this one 10-0 - made it 64-32.
Jones was playing in just his second college game after scoring 25 points in the season opener last week. That was a school record for a Kentucky debut. Jones finished with 12 points, 10 in the second half.
Kentucky's other star freshman, Doron Lamb, had 13 points.
It was a tough shooting night for the Pilots, who shot 53.5 percent from the field and 50.9 percent from the 3-point line in their first three games. But they missed their first 11 shots against the Wildcats and finished 18 of 59. The Wildcats shot 55 percent, while getting almost any shot they wanted.
It was the second meeting between the schools. Kentucky won 88-71 in Lexington during the 1989-90 season.
The game drew a crowd of 10,216 at the 19,980-seat Rose Garden, with a large number of fans wearing Wildcats blue.