The Wildcats led 4-0 after two innings, but much like Sunday's loss to VMI, could not make it hold up. UK starter Dylan Dwyer recorded six strikeouts in the first two innings, but was chased from his first career start after giving up four runs on five hits through three innings.
Kentucky (2-2) collected 12 hits, but struggled to come up with them at key opportunities. The Cats stranded 11 runners on the day.
Kyle Barrett, Austin Cousino, Max Kuhn, Ka'ai Tom and Micheal Thomas each had two hits for UK. Cousino, a junior centerfielder, also doubled and drove in two runs.
Second baseman/pitcher Eric Samples led USC Upstate (2-2) with a 3-for-5 day at the plate, drove in three runs and earned a save by pitching a perfect ninth inning for the Spartans. Zach Mitchell (1-0) earned the win for USC Upstate with two innings of one-run relief work.
UK will return to action in Norfolk, Va., on Friday when it faces St. John's at 11 a.m. ET on the campus on Old Dominion.