The No. 22 Wildcats (12-3) pounded out 19 hits, including four doubles and two home runs. Senior catcher Micheal Thomas, who had a career-best 4-for-6, three-RBI night in the first game of the weekend series, followed that up with a 3-for-4, six-RBI performance on Saturday.
Kentucky also got an SEC-leading eighth home run and 27th RBI from junior All-American A.J. Reed.
Austin Cousino, Max Kuhn, Ka'ai Tom, Dorian Hairston and Matthew Carson each had two-hit games for the Cats. Cousino raised his season average to .439, while Kuhn was also big in run-producing situations, driving in three.
"We did a great job at the plate," UK head coach Gary Henderson said. "We scored a bunch of runs without an error. We had good concentration and didn't try to do too much. We also did a great job of swinging at strikes and looking at balls. We took advantage when we were in advantage counts."
The offensive explosion somewhat overshadowed a great start by junior right-hander Chandler Shepherd (3-0) who allowed only two hits and two walks while striking out eight over seven innings of work.
Kentucky bounced back strong after blowing an 8-5 lead in the ninth inning of the series opener, losing 10-8 in extra innings.
Ball State (10-4) used four pitchers on the day, including starter Scott Baker (1-2), who was chased after giving up six runs in the second inning. The Cats had another six-run frame in the fifth inning.
The series concludes on Sunday at 1 p.m. ET at Cliff Hagan Stadium.