The Wildcats (24-8) will face No. 14 seed Wright State (26-8) in the opening round on Saturday at Memorial Coliseum in Lexington. The game is set to air live on ESPN2 at 11 a.m. ET.
Kentucky and Wright State are joined by No. 6 seed Syracuse (22-9) and No. 11 seed Chattanooga (29-3) in the Lexington pod. It marks the first time in program history that UK has been selected to host the first and second rounds. The second round will be played Monday at 6:30 p.m. ET.
"It's hard to go through a long season and play the kind of schedule that we played and get to this point, so I'm really proud of them," UK coach Matthew Mitchell said.
"We obviously overcame some adversity throughout the season that has us prepared for the tournament."
Ten of UK's 14 wins in the tournament have come under Mitchell. The Wildcats have reached the Elite eight in 2013, 2012 and 2010 under his guidance.
Wright State won the 2014 Horizon League Tournament championship. It marked the Raiders' first league tourney title, and this will also be their first appearance in the NCAA Tournament.
UK has never faced Wright State, but is 11-0 all-time against teams from the Horizon League.
The other No. 1 seeds are UConn (33-0) and Notre Dame (32-0).