The Wildcats will play two at home and two on the road.
South Carolina is the highest-ranked Kentucky opponent in the presason poll. The Gamecocks, projected as the favorite in the SEC East, come in at No. 9. Steve Spurrier's squad will visit Lexington on Oct. 4.
The Cats will travel to Baton Rouge, La., on Oct. 18 to play LSU, who comes in at No. 13.
Missouri, at No. 24, will play host to UK on Nov. 1 in Columbia. The Tigers were last year's susprise SEC East champions.
Defending national champion Florida State came in at No. 1 with Alabama, Oregon, Oklahoma and Ohio State rounding out the top five in the first season in which there will be a four-team playoff to end the year.