The Wildcats' senior defensive end picked off a South Carolina pass with 2:29 remaining in Saturday's game at Commonwealth Stadium, returning it 6 yards for a touchdown to lift UK to a 45-38 win over the Gamecocks.
Dupree also had six tackles and one tackle for loss in the game to rank among UK's team leaders.
His interception return helped UK overcome a 14-point deficit, marking the largest fourth-quarter comeback in program history. He was the first UK player to record a game-winning interception since John Rader against Indiana in 1998.
Dupree has 23 tackles this season with three tackles for loss and 1.5 sacks. He also has two quarterback hurries and one pass break-up. He is a member of the Ted Hendricks Award Watch List, given to the NCAA’s top defensive end, and the Chuck Bednarik and Bronko Nagurski Trophy Watch Lists, annually given to the best defensive player in college football.