The Cats batted around in the decisive frame, highlighted by an RBI double from Gunnar McNeill, an RBI single by Riley Mahan and a two-run double from Tristan Pompey.
Pompey, a freshman outfielder from Canada, went 2-for-3 on the night to lead UK at the plate. McNeill extended his hitting streak to 20 games, while Evan White had one hit to push his streak to 18 games.
No. 24 Kentucky (18-7) bounced back from a tough 5-4 loss to Northern Kentucky on Tuesday just 48 hours after taking two out of three games from No. 1 Florida on the weekend.
Zach Logue (pictured above) and Logan Salow each pitched three scoreless innings for the Cats, allowing only one hit and three walks. Salow (1-0) picked up his first win and lowered his season ERA to 1.62.
The Musketeers' Greg Jacknewitz (0-5) started and took the loss despite tossing one of his best games of the season. He allowed only two earned runs on five hits and three walks before exiting after 5-plus innings of work.
Xavier (8-17) got a solo home run from Stephen Haring to highlight its night at the plate.
Kentucky returns to action on Friday, traveling to Tennessee for a three-game series with first pitch slated for 6 p.m. ET at Lindsey Nelson Stadium.