The Commodores' sophomore right-hander allowed only five hits, improving to 5-2 on the season.
Jeren Kendall went 2-for-4 with two RBI to lead Vanderbilt (27-7, 8-5 SEC) at the plate. Connor Kaiser added two hits and drove in one for the Dores.
Kentucky (22-11, 8-5 SEC) got a second consecutive strong starting effort from Zack Brown(2-6), who allowed only three runs and struck out six over 6.2 innings. Vandy broke open a 1-0 game in the seventh with a pair of insurance runs.
Sophomore first baseman Evan White had a pair of doubles to lead UK at the plate.
The series will resume on Saturday at 3 p.m. ET at Charles Hawkins Field.