The victory was the 650th for Georgia coach Andy Landers, and the Bulldogs' third straight since a one-point loss to LSU.
Landers is the eighth women's basketball coach to reach the milestone, and only the second to do it one school. Tennessee coach Pat Summitt got her 901st win Sunday - all with the Lady Vols.
Kentucky kept the game close for most of the first half, and consecutive baskets by the Wildcats' Jenny Pfeiffer cut the margin to 29-23 with 6 minutes left. However, the Lady Bulldogs (16-5, 6-2 SEC) ended the half with a 12-4 run to build a 41-29 lead at the break.
Kentucky (15-5, 4-3) moved into the Top 25 this week for the first time since 1993 by handing Tennessee its first loss of the season last Thursday.
After Sarah Elliott's jumper pulled Kentucky within 51-37 early in the second half, Sherill Baker's jumper began an 11-0 run for Georgia that put the game out of reach.
Baker finished with 19 points, seven rebounds, seven assists and five steals. Megan Darrah added 14 points and Cori Chambers and Janese Hardrick had 13 apiece.
Eleia Roddy led Kentucky with 12 points, one shy of her career-high of 13. She was followed by Samantha Mahoney with 11 and Nastassia Alcius with 10.
Kentucky returns to action Sunday when it plays host to Florida. Tip-off in Memorial Coliseum is set for 12 p.m. and the game will be televised by Fox Sports Net South and aired on the Big Blue Sports Network (radio) with Neil Price. Kentucky defeated Florida earlier this season 80-65 in Gainesville, Fla., on Jan. 12. The game is sold out.