The victory would prove to be bittersweet, however. Early in the second half, Kentucky linebacker Wesley Woodyard tackled Bush on a 2nd and 6 play. Bush went down hard and did not get up. He lay on the ground several minutes before being wheeled off in a stretcher, lost presumably for the season with a broken tibia in his right leg.
Even without Bush, Kentucky had no answers for the Cardinal offense on the ground or in the air. Louisville continued the devastation to the Kentucky defensive line on the ground by committee, led by George Stripling, who himself carried the ball for 90 yards, including two touchdowns.
In the air, quarterback Brian Brohm, back for the first game after a season-ending knee injury, completed 19 of 31 passes for 242 yards and a touchdown.
Kentucky's Keenan Burton provided one of the few Kentucky bright spots offensively. Down 31-0 with just four minutes remaining in the first half, Woodson connected on a 73-yard touchdown pass to Burton to put the Cats on the board. With renewed vigor, the UK defense stopped the Cardinals from scoring for only the second time of the night.
Woodson then connected to Burton again, this time for 42-yards down to the Cardinal four yard line. Woodson completed the drive by making a four yard toss to Dicky Lyons Jr. to pull the Cats to within 17 points at 31-14 at the end of the half.
But the Cats would be unable to stop the Cardinal offense. Louisville would score four more touchdowns in the second half against a seemingly helpless Wildcats defense.
The Wildcats would add two scores of their own in the second half. One touchdown came on an 80-yard touchdown pass to Lyons. The second touchdown would come on a 100-yard kickoff return by Keenan Burton, who led both teams in all purpose yards with 311.
For Louisville, they must now regroup. They will need to overcome the devastating loss of Michael Bush if they are to win a bowl bid and compete for a national title. For Kentucky, it's back to the drawing board.