The victory keeps the Cajuns undefeated in Sun Belt Conference play at 3-0. Louisiana improved to 4-3 overall.
Tyrell Fenroy gained 128 yards on the ground moving within 30 yards of 1,000 and was the hero as he broke through the Arkansas State defensive line with 42 seconds remaining in the game to score the winning touchdown.
Louisiana (4-3, 3-0 Sun Belt), which leads the nation in rushing, was held to 189 yards on the ground after entering the game with a 332.2 average.
Arkansas State (4-3, 2-1) took a 16-14 lead on Josh Arauco's 41-yard field goal, his third of the game, with 7:55 left.
On the first play after the kickoff, Darius Glover stepped in front of a pass from Louisiana-Lafayette's Brad McGuire and returned it 29 yards for a touchdown and a 23-14 advantage.
McGuire, a redshirt freshman making his first start with Michael Desormeaux out with a knee injury, rushed for two touchdowns, including a 4-yard run with 4:16 left that cut the lead 23-21.
Louisiana converted two third-and-long situations on its game-winning 51-yard drive, including a 30-yard pass from McGuire to Derrick Smith.
Arkansas State took a 10-0 first-half lead on Arauco's 20-yard field goal and Corey Leonard's 10-yard scoring pass to Brandon Thompkins.
Louisiana cut the halftime margin to 10-7 on an 18-yard reverse pass from receiver Richie Falgout to Luke Aubrey.
McGuire's 1-yard touchdown run midway through the third quarter gave the Ragin' Cajuns a 14-10 lead before Arauco hit two more field goals.
Cajuns Come From Behind To Defeat ASU 28-23
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