Florida Atlantic (5-5,3-2 Sun Belt Conference) won its fourth straight game while handing the Ragin' Cajuns (5-5, 4-1) its first conference loss.
Smith was 17-for-26 for 290 yards, and Rob Housler caught two of Smith's touchdown passes and had 65 receiving yards.
Michael Desormeaux was 11-for-18 for 84 yards and two interceptions for Louisiana before being replaced by Brad McGuire, who was 7-for-8 for 48 yards. Chris Masson, the third quarterback used by the Ragin' Cajuns, was 6-for-7 for 72 yards with one touchdown and one interception.
The Owls took a 6-0 lead on Charles Pierre's 6-yard touchdown run in the first, and stretched the lead to 12-0 on a 13-yard touchdown pass to Chris Bonner from Smith.
Florida Atlantic made it 19-0 on Smith's second touchdown pass, a 14-yard strike to Rob Housler in the second quarter.
Louisiana pulled to 19-7 on a 14-yard touchdown run by Tyrell Fenroy, but a 10-yard touchdown run by Willie Rose gave Florida Atlantic a 26-7 lead at halftime.
Fenroy is now 17 rushing yards from tying Kevin Faulk's State of Louisiana career rushing record. He is one rushing touchdown from Brian Mitchell's UL mark of 47 career rushing touchdowns. He is two rushing scores from Mitchell's UL single-season mark of 19 rushing touchdowns and 42 rushing yards from Mitchell's UL single-season mark of 1,311 rushing yards.
Housler and Smith would hook up again on a 23-yard score in the third.
Trailing 40-7 in the fourth, Louisiana scored 22 points in the final quarter to shrink the final margin.
Owls Defeat the Ragin' Cajuns, 40-29
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