UL got to three different LSU pitchers for seven runs in the first three innings and then held on for dear life over the final six frames as the Tigers staged a rally.
LSU (11-3) finally caught the Cajuns, 9-9, in the eighth inning on Sean Ochinko's dramatic two-out, two-run homer.
But Hawkins quickly spoiled the Tigers' comeback when he whacked a low fast ball from LSU reliever Matty Ott into the left-field bleachers to boost UL to its first triumph against LSU since a 5-0 win in a 2002 NCAA Regional.
Hawkins had just one RBI, but it was the one that mattered. Other leading Cajuns included Les Smith (2-4, one RBI), Chad Keefer (2-4), and Travis Whipple (1-5, three RBI). Whipple smacked his first career home run in the first inning, while Thad Griffen (1-4) hit his first career bomb in the third.
Luke Wagley (1-1) earned the win on two innings, four hits, three runs (all earned), one walk and two strikeouts. Blake Wascom picked up his first save with two strikeouts and one hit allowed, entering in the ninth to close the game.
Alex Fuselier was the Cajuns' starter on the bump, throwing 4 1/3 innings and allowing, five runs, all earned, on six hits, four walks and two strikeouts.
LSU's Matty Ott (1-1) took the loss on Hawkins' home run, and finished with just one inning under his belt, giving up just the home run and striking two Cajuns out.
Cajuns Knock Off #3 LSU Tigers
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