Jefferson, whose brother and sister live in Louisville, visited last week during spring break. He spent a lot of time checking out Charlie Strong's program and decided after returning home he wanted to be part of the Cardinal family.
"I thought Louisville was the best place for me to play," Jefferson told InsideTheVille.com. "I liked all the coaches, Coach Strong, Coach [Kenny] Carter. I was up there last week, saw the campus and liked everything about the school, the players, coaches, campus...just everything."
A 6'4, 225-pound prospect, Jefferson was recruited by Louisville to play tight end, though he also saw time at defensive end last season in high school.
Last year as a junior, Jefferson recorded 65 tackles and six sacks on defense, and also caught 50 passes for 300 yards and two touchdowns.
Jefferson becomes Louisville's third 2012 commitment, joining Seneca defensive tackle Tyrone Pearson and Indianapolis offensive guard Sid Anvoots. All three prospects are rated as three-star players by Scout.com.