After being selected seventh in the Big East Conference last season, the Cardinals sit on top of the league heading into the new season.
Louisville received 24 of a possible 28 first-place votes and was tabbed as the preseason favorite to win the eight-team league.
U of L coach Charlie Strong said his team "can't worry about expectations," and noted several times in recent interviews that the poll was the same voters that selected his team at the bottom of the pack in his first two seasons.
The Cardinals went 7-6 overall last season, winning five of their last six regular-season games to finish 5-2 in Big East play and earn a share of their second league title since 2006.
South Florida (four first-place votes) was picked second in the league, followed Rutgers, Cincinnati and Pittsburgh.
Connecticut was selected sixth followed by Syracuse and league newcomer Temple.