Dieng, who broke the scaphoid bone in his left wrist on Friday against Missouri, will have surgery on the wrist on Tuesday and then will be sidelined four-to-six weeks while recovering.
"With a little luck, Gorgui will be back by the start of our Big East schedule," U of L coach Rick Pitino said. "We will miss his defensive presence and passing ability, but it's time for other guys to step up their performances."
Dr. Luis Scheker of the Kleinert Kutz Hand Care Center in Louisville will perform the surgery to insert a screw in his wrist. Dieng fell while taking a charge early in the first half of the Cardinals' 84-61 victory over Missouri.
Dieng played the rest of that game with his wrist taped but was not dressed in Saturday's game against Duke.
Dieng is averaging 8.2 points, 8.0 rebounds and two rebounds in five games. He was among the top 50 candidates for the Wooden Award and Naismith Award.
Sophomore Zach Price and senior Stephan Van Treese will be used in the middle for the Cardinals with Dieng on the sidelines.
POLLS UPDATED: The loss to Duke dropped the Cardinals a few spots in both the Associated Press and USA Today Coaches poll.
In the AP poll, U of L dropped from the No. 2 spot into No. 5. The Cardinals are now ranked No. 6 in the Coaches' poll.
U of L is 5-1 on the season and hosts Illinoi State on Saturday.
SMITH ON HONOR ROLL: Junior guard Russ Smith was named to the Big East Conference honor roll for the week after his performance in the Battle 4 Atlantis event in the Bahamas.
Smith averaged 17 points, six rebounds, 3.3 steals and three assists in three games. He's averaging 19.2 points a game this season.