Louisville is the favorite to claim its third NCAA Tournament national title heading into the tournament that begins on Thursday.
The Cardinals will make their 39th NCAA Tournament appearance as the No. 1 overall seed after winning the Big East Conference Tournament title in rousing fashion on Saturday night in Madison Square Gardens.
With the top overall seed, Louisville will get a much closer road to the title.
The Cardinals get to start the NCAA Tournament in Lexington at Rupp Arena and are the top seed in the Midwest Region, which is played in Indianapolis at Lucas Oil Stadium. The Final Four is played in Atlanta.
U of L will open the tournament against the winner of the Liberty-North Carolina A&T play-in game that will take place on Tuesday in Dayton.
U of L would then play either No. 8 Colorado State or No. 9 Missouri in the third round on Saturday in Rupp Arena.
The Midwest Regional dates are March 29 and 31 in Indianapolis. Duke is the No. 2 seed, Michigan State the No. 3 seed and Saint Louis is the No. 4 seed in the Midwest bracket.
Only four programs have more NCAA appearances than U of L, including Kentucky (52), North Carolina (44), UCLA (43) and Kansas (42).
Louisville made it to the Final Four last season for the ninth time. The Cardinals were ranked No. 2 heading into this season and are the only team in the country without a double-digit loss this season.
On Saturday, U of L won its 10th straight game and it did it coming from 16 points down in the second half to beat Syracuse.