Sophomore Kevin Ware scored 11, while Gorgui Dieng added 10 points.
Playing without senior guard Peyton Siva for most of the first half because of two early personal fouls, the Cardinals received key play from reserve guard Kevin Ware. Louisville led 45-31 at halftime.
Louisville outscored Oregon 42-34 in the paint and shot 54% from the floor.
U of L head coach Rick Pitino improves to 11-0 all-time in Sweet 16 games.
The Cardinals advance to the Elite 8 where they will face the winner of the Duke - Michigan State game.
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