Freshman righty Kyle Funkhouser had a rough start against No.6 Kentucky on Tuesday night, giving up a 2-run home run to Wildcat A.J. Reed in the first inning.
Despite the early deficit, the 9th-ranked Cardinals regained the lead in the third inning. Back-to-back walks issued to Adam Engel and Nick Ratajczak, followed by back-to-back balks by Kentucky freshman Kyle Cody plated a run. Ratajczak gave Louisville (22-6) a 3-2 lead when he scored on a fielders choice.
Kentucky tied the score at 3-3 in the 6th inning when Max Kuhn hit a solo home run off Louisville's Dace Kime.
The scored remained even until the 9th inning when both teams scored unearned runs, forcing the game into extra innings.
Kentucky (22-6) scored the winning run in the top of the 10th when J.T. Riddle reached on an error, advanced to second on a ground out and then took third on a passed ball. A sacrifice fly scored the unearned run.
"I think it comes down to defense," said Louisville head coach Dan McDonnell afterwards. "They played great defensively. Hats off to them. Unfortunately in the last two innings we didn't play clean baseball."
Louisville and Kentucky will meet for a second time this season on April 16 in Lexington.
"Great crowd, almost 5,000 people," said McDonnell. "It's a great rivalry, with two great programs and we are looking forward to playing them again in a few weeks."